He is a runner found suffering from a gunshot wound on a rooftop in Old Town, after Kyle Crane investigates the smoke signal he has activated.
When approached, Spider reveals that he too is a runner working with another man to discover the source of the epidemic. However, he was shot by bandits and begs Crane to finish his mission, directing him to collect some items and bring them to David at the Royal Canal, initiating the Legless Spiderquest.
Afterwards, Spider is able to make it to safety in the Harran University, where he remains.
Spider:"It's YOU! Crane! I've seen your face on the posters. You've got to help me." Crane:"What happened to you?" Spider:"I took a bullet from Rais's men. I'm a runner too. Well, almost. Look, I'm out of commission. Can you help me out? I need you to finish this run for me." Crane:"Hey, I'll get you to a shelter or something, but I've got other things to take care of." Spider:"You don't have anything more important than this. I gaurantee it." Crane:"Alright, tell me what you've got." Spider:"The source of the epidemic." Crane:"Where?" Spider:"David can show you. Here's a list and a bag with the things I've already collected. The rest is on you. When you've got it all, take it to David, and he'll tell you everything. You'll find him at the Royal Canal. Tell him Spider sent you." Crane:"What about you?" Spider:"I've got a safe house nearby. I'll be fine. Just help David. That's all that matters!"